Levi’s Stadium will host an exciting NFL Week 4 showdown between the New England Patriots and the San Francisco 49ers this Sunday afternoon. The New England Patriots are ranked 4th in the AFC East with a 1-2 record. Similarly, the San Francisco 49ers are placed last in the NFC West with 1-2 on the season after losing to the Rams last time out. According to the best NFL betting picks, the San Francisco 49ers will win this matchup.
The preview information
Date: September 29, Sunday | Time: 4:05 p.m. Eastern Time
Location: Levi’s Stadium, Santa Clara, California
TV: FOX
Stream: NFL+/Fubo TV
New England Patriots vs San Francisco 49ers Odds, Spread, Moneyline
Moneyline: New England Patriots (+450) vs San Francisco 49ers (-650)
Spread: New England Patriots (+10.5 – 115) vs San Francisco 49ers (-10.5 -105)
Total (O/U): New England Patriots (u40.5) vs San Francisco 49ers (o40.5)
New England Patriots
The New England Patriots played against the New York Jets in the previous matchup and lost with a pathetic 24-3. In that game, New England’s QB Jacoby Brissett completed 12 passes out of 18 for 98 yards. In rushing, Antonio Gibson managed five carries for 29 yards, while Demario Douglas took charge of the defense with seven receptions for 69 yards. This season, the Patriots are scoring 13.00 points per game, while allowing 19.00 points in each contest.
Top 3 Players
Jacoby Brissett: 368 Yds, 1 TD, 0 INT
Rhamondre Stevenson: 52 Car, 224 Yds, 2 TD
Hunter Henry: 12 Rec, 136 Yds, 0 TD
San Francisco 49ers
The San Francisco 49ers are coming to this week after losing to the Los Angeles Rams last time out with a final score of 27-24. Against the Rams, San Francisco’s QB Brock Purdy attempted 30 passes and completed 22 of them for 292 yards. Purdy went on to score a trio of touchdowns for the team. In rushing, Jordan Mason managed 19 carries for 77 yards, while Jauan Jennings contributed 11 receptions for 175 yards, along with three scores on defense.
Top 3 Players
Brock Purdy: 842 Yds, 4 TD, 1 INT
Jordan Mason: 67 Car, 324 Yds, 2 TD
Jauan Jennings: 18 Rec, 276 Yds, 3 TD
New England Patriots vs San Francisco 49ers Injury Report
New England Patriots
Jabrill Peppers (S) Is “?” Sunday vs San Francisco, Ankle
Ja’Whaun Bentley (LB) IR; is out for season, Pectoral
Oshane Ximines (LB) Is “?” Sunday vs San Francisco, Knee
Armon Watts (DT) IR, Undisclosed
Vederian Lowe (T) Is “?” Sunday vs San Francisco, Knee
Marte Mapu (LB) IR, Undisclosed
Jake Andrews (C) IR, Undisclosed
Sidy Sow (G) Is “?” Sunday vs San Francisco, Ankle
JaQuae Jackson (WR) IR, Knee
San Francisco 49ers
Trent Williams (T) Left last game, is “?” Sunday vs New England, Undisclosed
Javon Hargrave (NT) Is out indefinitely, Triceps
Jon Feliciano (G) IR, Undisclosed
Christian McCaffrey (RB) IR, Calf
George Kittle (TE) Is “?” Sunday vs New England, Hamstring
Deebo Samuel (WR) Is out indefinitely, Calf
Ambry Thomas (CB) IR, Undisclosed
Eli Mitchell (RB) IR, Hamstring
Kalia Davis (DT) IR, Knee
Brock Purdy (QB) Is “?” Sunday vs New England, Back
New England Patriots vs San Francisco 49ers Betting Trends
New England Patriots
New England are 1-4 SU in their last 5 games.
New England are 4-2 ATS in their last 6 games against San Francisco.
New England are 4-8 SU in their last 12 games against San Francisco.
New England are 4-1 ATS in their last 5 games on the road.
New England are 2-4 SU in their last 6 games when playing on the road against San Francisco.
New England are 0-6 SU in their last 6 games against an opponent in the National Football Conference.
The total has gone UNDER in 4 of New England’s last 5 games against an opponent in the National Football Conference West division.
The total has gone UNDER in 4 of New England’s last 5 games played in September.
San Francisco 49ers
San Francisco are 1-6 ATS in their last 7 games.
The total has gone OVER in 4 of San Francisco’s last 5 games.
San Francisco are 10-5 SU in their last 15 games.
The total has gone UNDER in 6 of San Francisco’s last 8 games against New England.
San Francisco are 1-7 ATS in their last 8 games at home.
San Francisco are 4-2 SU in their last 6 games when playing at home against New England.
The total has gone OVER in 6 of San Francisco’s last 9 games against an opponent in the American Football Conference.
The total has gone OVER in 5 of San Francisco’s last 6 games against an opponent in the American Football Conference East division.
San Francisco are 12-6 SU in their last 18 games played in September.
San Francisco are 4-2 ATS in their last 6 games played in week 4.
New England Patriots vs San Francisco 49ers Summary and Prediction
The New England Patriots are coming here after a shabby game, and have not much to boast about this season. The 49ers are not that great themselves, but are definitely the better team in this pairing. Take the San Francisco 49ers to win 30-12 this Sunday.
Moneyline: 49ers (-650)
Spread: Under 10.5
Total: Over 40.5
Predicted Score: 30-12, 49ers win.
For more sports content:
Follow me on X at @ErnestLeo, and follow us at @HardwoodHeroics and @GridironHeroics. You can also reach out to Ernest Hernandez via email at ernestleo@gmail.com. To read more of our articles and keep up to date on the latest sports news, click here!
Ernest also manages a YouTube account called Sports On Air, which has over 103 thousand subscribers. The channel contains interviews predominantly from the Philippine Basketball Association. They can be reached at sportsonairph@gmail.com.