The 6-7 San Francisco 49ers host the 7-6 Los Angeles Rams at Levi’s Stadium for their 14th regular season game on Thursday Night Football. Tonight is a must-win for the 49ers, who currently sit in 11th place in the NFC Playoff Picture and last in the NFC West division standings. With a win over the Rams, the 49ers would see their playoff hopes jump from 7% to 11%, while a loss would drop them to less than a 1% chance. The over/under is 49, while the home team is 2.5-point favorites.
The San Francisco 49ers rookie starter is dealing with an injury

49ers’ rookie running back Isaac Guerendo suffered an apparent foot injury midway through the fourth quarter in Week 14 against the Chicago Bears. Guerendo did not return for the remainder of the game despite a questionable designation. The rookie finished his first career start with 78 rushing yards on 15 carries and two touchdowns and caught both of his targets for 50 receiving yards.
Tests determined that Guerendo suffered a foot sprain. During Monday’s press conference, Kyle Shanahan told the media that they would evaluate him for the next couple of days. “We’ll evaluate him over the next few days and see if he’s got a shot (for Thursday),” Shanahan said on Monday afternoon via Lindsey Pallares of the team’s website.
What does his game status look like for TNF?

Isaac Guerendo was listed as a non-participant on Monday and Tuesday but upgraded to a limited participant on Wednesday’s practice. The San Francisco 49ers released the short week’s final injury report on Wednesday, listing him as questionable. According to Adam Schefter of ESPN, their rookie running back plans to play Thursday night against their divisional rivals.
With the fantasy football playoffs starting tonight:
49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed as questionable, per sources. Guerendo insists he “feels good.” pic.twitter.com/WClJ52lva3
— Adam Schefter (@AdamSchefter) December 12, 2024
Who starts at RB if he cannot play?

Patrick Taylor Jr. will start at running back if Isaac Guerendo cannot play against the Los Angeles Rams on Thursday night. Taylor served as the backup running back and filled in for the injured Guerendo against the Chicago Bears. He rushed for 25 yards on seven carries and one touchdown in a season-high 20 snaps.