The Buffalo Bills are scheduled to take on the Indianapolis Colts at Lucas Oil Stadium this Sunday afternoon to continue the NFL season. The Buffalo Bills are at the top of the AFC East after winning seven games and losing two. Meanwhile, the Indianapolis Colts are ranked no. 2 in the AFC South with an overall 4-5 record on the season. The top NBA Week 10 betting experts predict the Buffalo Bills to grab a win in this matchup.
The preview information
Date: November 10, Sunday | Time: 1:00 p.m. Eastern Time
Location: Lucas Oil Stadium, Indianapolis, Indiana
TV: CBS
Stream: NFL+/Fubo TV
Buffalo Bills Vs Indianapolis Colts Odds, Spread, Moneyline
Moneyline: Buffalo Bills (-197) vs Indianapolis Colts (+172)
Spread: Buffalo Bills -4.5 (+104) vs Indianapolis Colts +4.5 (-117)
Total (O/U): Buffalo Bills (o46.5) vs Indianapolis Colts (u46.5)
*All odds are subject to change depending on the time of this posting

Buffalo Bills
The Buffalo Bills played the Miami Dolphins last week and won the game with a final score of 30-27. Against Miami, Buffalo’s QB Josh Allen went for 235 yards, completing 25 passes out of 39. Allen managed to score three touchdowns in that game, with a single interception. James Cook took care of Buffalo’s rushing with ten carries for 44 yards. On defense, Ray Davis managed a pair of receptions for 70 yards, along with a solo TD.
Top 3 Players
Josh Allen: 2,001 Yds, 17 TD, 2 INT
James Cook: 109 Car, 496 Yds, 7 TD
Khalil Shakir: 42 rec, 471 Yds, 2 TD
Indianapolis Colts
The Indianapolis Colts are coming here after playing the Minnesota Vikings in the previous week. In that game, Indianapolis’ Joe Flacco led the offense with 16 pass-completions for 27 attempts in 179 yards. Flacco managed a solo interception in that game. In terms of rushing, Jonathan Taylor led the team with 13 carries for 48 yards, while Josh Downs took charge of the defense with six receptions for 60 yards.
Top 3 Players
Anthony Richardson: 958 Yds, 4 TD, 7 INT
Jonathan Taylor: 105 Car, 502 Yds, 5 TD
Alec Pierce: 19 Rec, 435 Yds, 3 TD
Buffalo Bills Vs Indianapolis Colts Injury Report
Buffalo Bills
Amari Cooper (WR) Is “?” Sunday vs Indianapolis, Wrist
Matt Milano (LB) IR, Biceps
Casey Toohill (DE) Is “?” Sunday vs Indianapolis, Knee
Reggie Gilliam (RB) Is “?” Sunday vs Indianapolis, Hip
Shane Buechele (QB) IR, Neck
Christian Benford (CB) Is “?” Sunday vs Indianapolis, Wrist
DeWayne Carter (DT) IR, Wrist
Keon Coleman (WR) Left last game, is “?” Sunday vs Indianapolis, Wrist
Travis Clayton (T) IR, Shoulder
Tylan Grable (T) IR, Groin
Indianapolis Colts
Samson Ebukam (LB) IR, Achilles
Tyquan Lewis (DT) IR, Undisclosed
Juwann Winfree (WR) IR, Undisclosed
Will Fries (G) IR, Tibia
Bernhard Raimann (T) Is “?” Sunday vs Buffalo, Concussion
Jelani Woods (TE) IR, Toe
Trevor Denbow (S) IR, Knee
Wesley French (C) IR, Ankle
JuJu Brents (CB) IR, MCL
Daniel Scott (S) IR, Achilles
Jaylon Carlies (S) IR, Calf
Ryan Coll (T) IR, Undisclosed

Buffalo Bills Vs Indianapolis Colts Betting Trends
Buffalo Bills
Buffalo are 13-3 SU in their last 16 games.
Buffalo are 2-4 ATS in their last 6 games against Indianapolis.
Buffalo are 4-9 SU in their last 13 games against Indianapolis.
The total has gone UNDER in 5 of Buffalo’s last 6 games on the road.
Buffalo are 0-6 SU in their last 6 games when playing on the road against Indianapolis.
Buffalo are 11-3 SU in their last 14 games against an opponent in the American Football Conference.
The total has gone OVER in 4 of Buffalo’s last 6 games against an opponent in the American Football Conference South division.
Buffalo are 1-5 ATS in their last 6 games played in November.
Indianapolis Colts
Indianapolis are 6-1 ATS in their last 7 games.
The total has gone UNDER in 4 of Indianapolis’ last 5 games.
The total has gone UNDER in 7 of Indianapolis’ last 10 games against Buffalo.
Indianapolis are 4-1 ATS in their last 5 games at home.
Indianapolis are 6-0 SU in their last 6 games when playing at home against Buffalo.
Indianapolis are 6-0 ATS in their last 6 games against an opponent in the American Football Conference.
Indianapolis are 6-1 SU in their last 7 games against an opponent in the American Football Conference East division.
The total has gone UNDER in 4 of Indianapolis’ last 6 games played in November.
The total has gone UNDER in 6 of Indianapolis’ last 8 games played on a Sunday.
Buffalo Bills Vs Indianapolis Colts Summary and Prediction
The Buffalo Bills are definitely stronger than the Indianapolis Colts on both ends, and will easily dominate the home-team. The Colts have suffered in the past against Buffalo, and will continue here as well. Take the Buffalo Bills to win with a final score of 24-20.
Moneyline: Bills (-197)
Spread: Under 4.5
Total: Over 46.5
Predicted Score: 24-20, Bills win.

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