Highmark Stadium will host a week 1 NFL matchup between the Arizona Cardinals and the Buffalo Bills on September 8th. The Arizona Cardinals are keeping their fingers crossed to start off the regular season well after losing to the Broncos in the third week of the preseason. The Bills also hope to make up for their preseason finale defeat against the Panthers. The top NFL betting experts expect the Buffalo Bills to win this game.
Arizona Cardinals vs Buffalo Bills NFL Week 1 Preview Information
Date: September 8, Sunday | Time: 1:00 p.m. Eastern Time
Location: Highmark Stadium, New York
TV: CBS
Stream: NFL+/Fubo TV
Moneyline: Arizona Cardinals (+220) vs Buffalo Bills (-275)
Spread: Arizona Cardinals (+6 – 110) vs Buffalo Bills (-6 -110)
Total (O/U): Arizona Cardinals (u48) vs Buffalo Bills (o48)
Buffalo Bills Vs Arizona Cardinals
Arizona Cardinals
The Arizona Cardinals took on the Denver Broncos in the last preseason game and lost with a final score of 38-12. This season will be Arizona’s second under head coach, Monti Ossenfort. The Cardinals hope to improve from their sad 4-13 record from last year. As per the preseason stats, the Cardinals are scoring an average of 19.41 points in each game, while allowing opponents to grab 26.76 points per contest.
Top 3 Players:
Kyler Murray: 1,799 Yds, 10 TD, 5 INT (2023)
Budda Baker: 58 Solo, 0 FF, 0 INT, 0 PD (2023)
Zay Jones: 34 Rec, 321 Yds, 2 TD (2023)
Buffalo Bills
The Buffalo Bills played the Carolina Panthers in week 3 of the NFL preseason and lost the game 31-26. This season will be Buffalo’s eighth season under Sean McDermott as head coach. As a unit, the Bills are scoring an average of 26.63 points in each game, with 238.37 passing yards. On defense, the Bills are allowing their opponents to get away with an average of 18.68 points in each contest played.
Top 3 Players:
Josh Allen: 22 Yds, 0 TD, 0 INT
Taylor Rapp: 1 Solo, 0 FF, 0 INT, 0 PD
James Cook: 10 Car, 27 Yds, 0 TD
Arizona Cardinals vs Buffalo Bills NFL Week 1 Injury Report
Arizona Cardinals
No injuries
Buffalo Bills
Mitchell Trubisky, QB, Is out indefinitely, Knee
Curtis Samuel, WR, Is “?” Sunday vs Arizona, Toe
Matt Milano, LB, IR, Biceps
Marquez Valdes-Scantling, WR, Is “?” Sunday vs Arizona, Neck
Damar Hamlin, S, Is “?” Sunday vs Arizona, Hamstring
Quintin Morris, TE, Is “?” Sunday vs Arizona, Shoulder
Buffalo Bills Vs Arizona Cardinals
Arizona Cardinals vs Buffalo Bills NFL Week 1 Betting Trends
Arizona Cardinals
The total has gone OVER in 4 of Arizona’s last 6 games.
Arizona are 4-16 SU in their last 20 games.
Arizona are 1-7 ATS in their last 8 games against Buffalo.
Arizona are 2-6 SU in their last 8 games against Buffalo.
Arizona are 2-10 SU in their last 12 games on the road.
Arizona are 1-4 SU in their last 5 games when playing on the road against Buffalo.
Arizona are 1-5 ATS in their last 6 games against an opponent in the American Football Conference East division.
Arizona are 4-1 ATS in their last 5 games played in September.
The total has gone UNDER in 4 of Arizona’s last 6 games played in week 1.
Buffalo Bills
Buffalo are 5-10 ATS in their last 15 games.
The total has gone OVER in 4 of Buffalo’s last 5 games.
Buffalo are 6-1 SU in their last 7 games.
The total has gone OVER in 6 of Buffalo’s last 7 games against Arizona.
Buffalo are 4-1 SU in their last 5 games at home.
Buffalo are 4-1 SU in their last 5 games when playing at home against Arizona.
The total has gone UNDER in 4 of Buffalo’s last 5 games against an opponent in the National Football Conference.
Buffalo are 5-0 ATS in their last 5 games against an opponent in the National Football Conference West division.
Buffalo are 6-2 ATS in their last 8 games played in September.
The total has gone UNDER in 9 of Buffalo’s last 11 games played in week 1.
Arizona Cardinals vs Buffalo Bills NFL Week 1 Summary and Prediction
The Buffalo Bills are ridden with injuries at the moment, but are still the stronger team. The Cardinals are severely lacking in offense and need to be more aggressive here. The Arizona Cardinals will be winning this game with a predicted score of 31-14.
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